Molecular Formula | C18H23N5O2 |
Molar Mass | 341.41 |
Storage Condition | Desiccate at RT |
MDL | MFCD30543744 |
biological activity | HLI373 is a potent Hdm2 inhibitor. HLI373 inhibits Hdm2 ubiquitin ligase activity. HLI373 is effective in inducing apoptosis of tumor cells (sensitive to DNA damaging agents). It has anti-malaria activity. |
Target | Hdm2; Apotosis; Antimalarial |
Cell Line: | Wild type p53 mouse embryo fibroblasts (MEFs), and p53-deficient MEFs U2OS cells |
Concentration: | 3, 10, 15 μM 5, 10 μM |
Incubation Time: | 15 hours 8 hours |
Result: | Increased cell death in wild type p53 MEFs in a dose-dependent manner, p53-deficient MEFs were relatively resistant. Blocked p53 degradation caused by co-transfection with plasmids encoding p53 and Hdm2. |